David A Lomas Selected Research

Familial encephalopathy with neuroserpin inclusion bodies

9/2016	Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).
12/2015	Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.
3/2013	A novel interaction between aging and ER overload in a protein conformational dementia.
6/2008	The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB.
5/2005	Molecular mousetraps, alpha1-antitrypsin deficiency and the serpinopathies.
5/2002	Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro.

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David A Lomas Research Topics

Disease

96	Chronic Obstructive Pulmonary Disease (COPD) 03/2022 - 07/2007
43	Emphysema 01/2021 - 06/2002
30	Dementia (Dementias) 11/2019 - 05/2002
20	Fibrosis (Cirrhosis) 01/2022 - 03/2002
18	Brain Diseases (Brain Disorder) 11/2019 - 10/2002
16	Inflammation (Inflammations) 01/2021 - 05/2006
15	Liver Diseases (Liver Disease) 01/2021 - 03/2002
15	Alzheimer Disease (Alzheimer's Disease) 12/2013 - 03/2002
9	Thrombosis (Thrombus) 05/2009 - 04/2003
7	Pneumonia (Pneumonitis) 07/2021 - 12/2016
6	Lung Diseases (Lung Disease) 05/2021 - 02/2012
6	Familial encephalopathy with neuroserpin inclusion bodies 09/2016 - 05/2002
6	Hepatocellular Carcinoma (Hepatoma) 05/2013 - 07/2003
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 02/2005
5	Neonatal hemochromatosis 05/2013 - 03/2002
4	Cardiovascular Diseases (Cardiovascular Disease) 06/2020 - 07/2013
4	Amyloidosis 12/2019 - 03/2002
4	Disease Progression 01/2017 - 10/2012
3	Cachexia 05/2020 - 08/2012
3	Atherosclerosis 01/2018 - 01/2015
2	Weight Loss (Weight Reduction) 12/2021 - 05/2020
2	Epilepsy (Aura) 09/2016 - 08/2004
2	Vasculitis (Vasculitides) 09/2013 - 03/2013
2	Infections 09/2013 - 05/2006
2	Pancreatic Neoplasms (Pancreatic Cancer) 08/2013 - 10/2012
2	Obstructive Lung Diseases (Obstructive Lung Disease) 03/2012 - 11/2010
2	Ischemic Stroke 05/2011 - 03/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2010 - 10/2007
2	Angioedema 01/2009 - 04/2003
2	Necrosis 02/2008 - 09/2006
2	Hepatitis 11/2004 - 08/2003
1	Cholelithiasis 01/2022
1	Liver Neoplasms (Liver Cancer) 01/2022
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Fatigue 05/2020
1	Anorexia 05/2020
1	Anemia 05/2020

Drug/Important Bio-Agent (IBA)

44	Biomarkers (Surrogate Marker)IBA 07/2021 - 09/2010
36	PolymersIBA 01/2021 - 05/2002
33	NeuroserpinIBA 11/2019 - 05/2002
27	Proteins (Proteins, Gene)FDA Link 12/2021 - 03/2002
15	SerpinsIBA 11/2019 - 10/2002
14	vilanterolIBA 06/2021 - 01/2017
14	GSK573719IBA 06/2021 - 01/2017
14	fluticasone furoate FDA Link 06/2021 - 01/2017
12	Fibrinogen (Factor I)FDA Link 07/2021 - 11/2011
11	GoldIBA 12/2018 - 09/2010
9	Peptide Hydrolases (Proteases)FDA Link 05/2021 - 05/2002
9	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 12/2020 - 09/2004
9	Peptides (Polypeptides)IBA 01/2014 - 03/2003
8	Adrenal Cortex Hormones (Corticosteroids)IBA 06/2021 - 07/2012
7	AntithrombinsIBA 05/2009 - 04/2003
5	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 08/2014 - 03/2011
5	Amyloid (Amyloid Fibrils)IBA 12/2013 - 10/2007
4	Pharmaceutical PreparationsIBA 01/2021 - 08/2003
4	nasIBA 02/2012 - 03/2009
3	EnzymesIBA 01/2022 - 03/2013
3	C-Reactive ProteinIBA 07/2021 - 12/2012
3	CalciumIBA 11/2019 - 08/2014
3	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2019 - 03/2013
3	Protease Inhibitors (Protease Inhibitor)IBA 01/2016 - 11/2010
3	Serine Proteases (Serine Protease)IBA 09/2013 - 03/2010
3	Bronchodilator Agents (Bronchodilators)IBA 08/2012 - 09/2011
3	Amyloid beta-PeptidesIBA 04/2010 - 04/2009
3	amyloid beta-protein (1-42)IBA 04/2009 - 03/2003
3	alpha 1-Antichymotrypsin (alpha 1 Antichymotrypsin)IBA 01/2009 - 03/2003
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 05/2006
2	IronIBA 05/2020 - 02/2011
2	Muscarinic AntagonistsIBA 05/2018 - 04/2018
2	6- (5- ((cyclopropylamino)carbonyl)- 3- fluoro- 2- methylphenyl)- N- (2,2- dimethylprpyl)- 3- pyridinecarboxamideIBA 01/2018 - 03/2012
2	Budesonide (Pulmicort)FDA LinkGeneric 01/2018 - 01/2017
2	p38 Mitogen-Activated Protein KinasesIBA 01/2018 - 03/2012
2	Monoclonal AntibodiesIBA 01/2018 - 09/2010
2	Formoterol Fumarate (Oxis)FDA Link 01/2018 - 01/2017
2	Fluticasone (Cutivate)FDA LinkGeneric 01/2018 - 03/2012
2	AsparagineIBA 12/2015 - 10/2012
2	Receptor for Advanced Glycation End ProductsIBA 10/2015 - 10/2013
2	P-2 (P 2)IBA 01/2015 - 12/2010
2	Interleukin-8 (Interleukin 8)IBA 08/2014 - 09/2013
2	Messenger RNA (mRNA)IBA 01/2014 - 10/2009
2	Interleukin-6 (Interleukin 6)IBA 09/2013 - 11/2011
2	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 08/2013 - 03/2010
2	Blood Proteins (Serum Proteins)IBA 07/2013 - 01/2009
2	SmokeIBA 04/2013 - 12/2009
2	Amino Acids FDA Link 03/2013 - 10/2012
2	Glutamine (L-Glutamine)FDA Link 10/2012 - 08/2012
2	Biological ProductsIBA 09/2011 - 04/2010
2	Tissue Plasminogen Activator (Alteplase)FDA Link 03/2011 - 08/2004
2	Heparin Cofactor IIIBA 01/2009 - 09/2006
2	PrionsIBA 09/2004 - 10/2002
1	Insulin (Novolin)FDA Link 01/2021
1	CytokinesIBA 01/2021
1	omega-Chloroacetophenone (Mace)IBA 06/2020
1	Heme (Haem)IBA 05/2020
1	Hemoglobins (Hemoglobin)IBA 05/2020
1	Small Interfering RNA (siRNA)IBA 08/2018
1	GlucocorticoidsIBA 05/2018
1	Tiotropium Bromide (Spiriva)FDA Link 04/2018

Therapy/Procedure

34	Therapeutics 03/2022 - 03/2002
14	Nebulizers and Vaporizers (Inhaler) 03/2022 - 01/2017